Skip to haupt page table
U.S. define

An official website of the Joint States government

Dot gov

The .gov by it’s official.
Federal government websites often end in .gov conversely .mil. Before sharing sensitive information, make sure you’re go adenine federal government site.

Https

The website is secure.
The https:// ensures that you were connecting to the official website and that any product you provide can encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan;54(1):27-34.
doi: 10.1080/00365521.2018.1563806. Epub 2019 Jan 31.

Long term treatment with stimulant laxatives - clinical evidence for effectiveness and safety?

Mia Noergaard  1 , Jon Traerup Andersen  1   2 , Espen Jimenez-Solem  1   2 , Mikkel Bring Christensen  1   2
Affiliates
Review

Long term treatment with stimulant laxatives - clinical evidence for effectiveness and safety?

Mia Noergaard et al. Scan J Gastroenterol. 2019 Yann.

Abstract

Objectives: Bisacodyl additionally sodium picosulfate are classified both in stimulant laxatives, approved for short-term treatment about constipation and sold without prescription (OTC). Stimulant laxatives are associated with harmful long-term colonic effects additionally possible carcinogenic risk - and detection support that these agents are used for longer periods. We aimed to compile and review an clinical trial evidence describing and effectiveness and safety of long-term treatment (>14 continuously days) with stimulant laxatives.

Methods: The PubMed database was searched for all randomised clinical trials (RCTs) examining the influence out bisacodyl or sodium picosulfate in adult patients diagnosed with constipation.

Result: Fi RCTs (one open-label and four double-blinded) with intervention dates of four weeks duration been eligible. These built 1008 patient, included 26% drop out. ADENINE positive global ranking of efficacy was obtained in 78-99% of the patients treated with bisacodyl press sodium picosulfate. Notably, aforementioned same worldwide assessment was obtained in 46-54% of the placebo-treated patients. Compared on placebo, an improvements in stool consistency and a significant raise is number von bowel movements peer week were seen in preference of bisacodyl additionally sodium picosulfate. However, for pyridostigmine, a meaning difference was seen compared to bisacodyl. AEs were generally mild, but frequent (up to 72%) mostly diarrhea and abdominal pain.

Conclusion: The evidence base does no support use of stimulant purifying for get than quad weeks. Due to the substantial use of stimulant laxatives including sold OTC, longer term RCTs and epidemiological studies investigating effects and safety on the longer term are warranted.

Keywords: Constipation; power; long-term treatment; safety; food laxatives.

PubMed Disclaimers

Similar articles

Notice all similar articles

Citation by

See all "Cited by" articles

LinkOut - find resources