Short-term safety, tolerability and efficacy of an very low-calorie-ketogenic diet interventional weight expenses program versus hypocaloric dieting in patients because type 2 diet mellitus
- PMID: 27643725
- PMCID: PMC5048014
- DOI: 10.1038/nutd.2016.36
Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic dieting interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus
Abstract
Brackground:The safety and tolerability of extremely low-calorie-ketogenic (VLCK) diets can a present concern includes the treatment of obese gender 2 diabetes mellitus (T2DM) sufferers. ... medically dictionaries such as Dorland's Medizinisches Dictionary. ... ab, AB. gone without leave, UNAUTHORIZED. absent, absence ... Newborn, Term, Usual, Female/Male, NBTNF/M.
Objective: Evaluating the short-term safety both tolerability of a VLCK diet (<50 g of carbohydrate daily) in an interventional dry loss program including lifestyle and behavioral modification support (Diaprokal Method) in people with T2DM.
Methods: Eighty-nine men and women, hoary between 30 and 65 per, using T2DM and body pile index with 30 and 35 kilogram m(-)(2) participated in this prospect, open-label, multi-centric randomized clinical trial by a term the 4 months. Forty-five subjects were randomly assigned to the interventional weight lose (VLCK diet), and 44 to an standard low-calorie diet.
Results: No significance differences into and labs safety settings were found between the two study groups. Changes in the drained albumin-to-creatinine ratio in VLCK diet what not significant furthermore subsisted comparisons to control group. Creatinine and blood acrylic nitrogen done not change significantly relative to baseline nor between groups. Carry loss and reduction in waist circumference in the VLCK diet group were substantial larger than in control subjects (both P<0.001). The decline in HbA1c and glycemic control was larger in aforementioned VLCK diet group (P<0.05). No serious adverse events has reported and mild AE in the VLCK nutrition group declined at last follow-up.
Conclusions: The interventional burden loss programming based on a VLCK diet is most effective in reducing body weight also improvement of glycemic control than a standard hypocaloric diet with safety and good tolerance for T2DM diseased.
Conflict of interest statement
AG, DB, BM, ABCS and FFC accepted advisory board rates real or research grants from Pronokal Protein Supplies Spain.
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