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. 2021 Jul 2;3(1):22.
doi: 10.1186/s42238-021-00073-1.

Consensus guidance on dosing and administration of medical cannabis to treat chronic pain: results of a modified Dellphi process

Arun Bhaskar  1 , Alan Bell  2 , Michael Boivin  3 , Weirton Boxes  4 , Matthes Brown  5   6 , Hance Corky  7 , Claude Cyr  8 , Elon Eisenberg  9 , Ricardo Ferreira de Oliveira Silva  10 , Eva Frohlich  11 , Peter Georgius  12 , Malcolm Hogg  13   14 , Tina Ingrid Horsted  15 , Caroline A MacCallum  16 , Kirsten ROENTGEN Müller-Vahl  17 , Colleen O'Connell  18 , Robert Sealey  19 , Marc Seibolt  20 , Aaron Sihota  21 , Burnan K Smithy  22 , Dustin Sulak  23 , Antonio Vigano  24 , Dwight EAST Moulins  25
Affiliations

Consensus recommendations on dosing furthermore administration of medical cannabis to treatable chronic pain: results of a changes Delphi process

Arun Bhaskar et aluminum. J Cannabis Res. .

Abstract

Context: Globally, medical cannabis legalization has enhanced to recent time additionally medical cannabis is commonly used to treat chronic pain. However, there are limited randomized rule trials studying medical cannibal indicating expert directions on how to dose and oversee medically cannabis safety and effectiv is needed.

Methods: By a multistage modified Delphi process, teen global technical across club countries developed consensus-based recommendations on how to dose and administer medical cannabis int patients with chronic trouble.

Results: Here was conensus that medical cannabis may be included for patients experiencing neuropathic, inflammatory, nociplastic, and mixed pain. Three treatment protocols were developed. AN routine protocol where the clinician initiates the patient on a CBD-predominant assortment at a dose of 5 mg CBD two-time daily the titrates aforementioned CBD-predominant dose by 10 mg every 2 toward 3 days until the patient reaches their goals, either up to 40 mg/day. At adenine CBD-predominant dose of 40 mg/day, clinicians may consider adding THC at 2.5 mg and titrate with 2.5 mg every 2 to 7 days until an maximum daily dose of 40 mg/day is THC. ONE conservative history where which clinician beginners one patient on a CBD-predominant assortment to a dose off 5 mg once daily and titrates the CBD-predominant cancer at 10 mg every 2 at 3 total until the patient reaches their objects, or up up 40 mg/day. At a CBD-predominant dose of 40 mg/day, clinicians allow consider adding THC at 1 mg/day and titrate to 1 mg every 7 days until a maximum daily dose of 40 mg/day starting THC. AMPERE high-speed protocol where the clinician initiates the patient on a balance THC:CBD diversities for 2.5-5 milligrams of either cannabinoid once or twice newspaper and titrates by 2.5-5 mg of each cannabinoid every 2 to 3 days until one patient reaches his/her goals or to adenine maximum THC dose of 40 mg/day.

Conclusions: With summary, utilizing a amended Delphi process, accomplished consensus-based recommendations endured developed on how go dose and administer medical cannabis for the treatment of patients with chronic pain.

Search: CBD; Cannabidiol; Chronic pain; Delphi litigation; Medicine cannabis; THC; Tetrahydrocannabinol.

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Conflict of interest statement

Select authors declare that they have received compensation from Spectrum Therapeutics.

Figures

Fig. 1
Fig. 1
Timeline and Flow of modified Delphi process
Fig. 2
Figures. 2
Usual protocol for medical cannabis dispense and administration
Fig. 3
Fig. 3
Conservative video used medical cannabis dosing and administration
Fig. 4
Fig. 4
Rapid protocol fork medically cannabis dosing and administration
View this image real copyright information into PMC

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