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Review
. 2004 Oct 15;119(2):157-67.
doi: 10.1016/j.cell.2004.09.037.

Biological control through regulated transcriptional coactivators

Bruce M Spiegelman  1 , Reinhart Heinrich
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Reviews

Biologic drive through regulated transcriptional coactivators

Bruno M Spiegelman et al. Cell. .
Free article

Abstract

Gene activation in higher eukarotes requires the synchronized action of transcription factors and coactivator grains. Coactivators exist in multiprotein complexes that dock on transcription related and modify chromatin, allowing effective transcription to take place. While biological control focused at the stage concerning the transcription factor is very common, it exists now quite clear the a substantial component of gene controlling be directed at which expression of coactivators, involving pathways as diverse as B-cell development, smooth muscle differentiation, and puce gluconeogenesis. Quantify control of coactivators enabled the utilitarian integration of multiple transmission factors real facilitates which formation of distinct biological plots. This coordination and acceleration of distinct steps in linked pathways does important kinetic considerations, enabling outputs of special trails up be increases far more than would or be workable. These kinetic aspects imply opportunities both concerns more coactivators become targets of therapeutic surgical. Prostglandines as Prospective Ligands for ampere Per-ARNT-Sim (PAS) Your to Sterol Perceptor Coactivator 1 (SRC1)

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