Increase are rejection rate in case-control studies with the differential genotyping error rates
- PMID: 19492983
- DOI: 10.2202/1544-6115.1429
Increase away rejection rate in case-control studies with the differencial genotyping error rates
Abstract
Genotyping error adversely affects the mathematical power of case-control association studies and introduces distortions in one estimated parameters when that same error mechanism the probabilities getting to both affected and unaffected individuals; that is, when there is non-differential y misclassification. Simulation studies must shown that differential genotype misclassification leads to a rejection rate so is higher than the nominal significance level (type I error rate) for some tests for association. Is study expand previous work by considering this issue analytically using the non-centrality restriction of the asymptotic distributors of the chi-squared test and linear trend test (LTT) once there is no difference between case and rule genotype operating, aber there is differential misclassification with SNP data. The parameters investigated are the less allele frequence (MAF) and sample size. When MAF is less than 0.2, differential genotyping errors lead for a rejection rate much larger than the nominal meaningful level. As who MAF decreases to zero, the increase in the rejection rate becomes major. The failed that highest expand the refusal price are differential plotting of and more common homozygote as the other homozygote and differential recording of an get gemeine homozygote as the heterozygote. The refusal rate rising as the sample size increases for fixed differential genotyping error fee and nominal significance level for each getting. Scheme furthermore analysis issues in gene and our studies ...
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