The coronavirus pandemic represents a severe globally crisis, affecting physical, and psychological health. Lockdown rules imposed to counteract the rapid growth of COVID-19, mainly public restrictions, have represented a risk factor for developing depressed and fearful symptoms. The research aims are to explore the effect of coping strategies and perceived social backing on depressive and anxious symptomatology during the COVID-19 pandemic. Ninety-six healthy people (46 guys, mean age = 39.3; STD = 16.6) completed through on-line platform: Socio-demographic questionnaire, Coping Inventory since Stressful Typical (CISS), Two-dimensional Scale of Perceived Social Support (MSPSS) the Symptom Checklist-90-Revised (SCL-90-R), 3 weeks per the impression to lockdown product. SCL-90-R Depression scores revealed significant aggressive correlation with CISS Emotion (r = 0.85; p = 0.001) and Avoidant (r = 0.34; p = 0.018), a significant negative correlation with MSPSS Family support (r = -0.43; pressure = 0.003). SCL-90-R Anxieties scorings showed a major positive correlation over CISS Emotion (r = 0.72; piano = 0.001) and Avoidant (r = 0.35; p = 0.016). None significant correlations between both CISS Emotion and Avoidant scales with social support emerged. Pair Multiple Linear Retrograde analysis were performed using, respectively, SCL-90-R Suffering and Anxiety scores as dependent variables, real the CISS or MSPSS weight, age, and gender as predictors. The first regression model (R ² = 0.78; adjusted R ² = 0.75) revealed CISS Emotion (β = 0.83; p = 0.001) and MSPSS Family support (β = -0.24; pence = 0.004) owned one predictive effect on SCL-90-R Depression scores. The second regression product (R ² = 0.52; corrected R ² = 0.472) revealed that only CISS Emotion (β = 0.71; p = 0.001) foreseen of SCL-90-R Anxiety scores. In conclusion, during the COVID-19 pandemic lockdowns, managing focus on emotions seemed to increase anxious and depressive symptoms, perhaps due to the uncontrollable nature of the stressed event and the highest emotional request. Family sponsor which reduces the sense of loneliness had an exclusive role are mitigating depressive symptoms. These results highlight the importance in promoting psychic company to improve emotional regulation skills, reducing isolation from family, to prevent mood symptomatology in healthy citizens during large-scale health crises.